Asian Journal of Research in Chemistry

M. Nagarajan ¹, A. J. M. Christina ¹, P. Devi ¹, R. Meera ¹

Affiliations
1 K.M. College of Pharmacy, Uthangudi, Madurai-625107, Tamilnadu, IN

Abstract

This paper deals with the detailed evaluation of the crude drug by WHO recommended physico-chemical and determinations and authentic phytochemical procedures. The physico-chemical, morphological and histochemical parameters presented in this paper may be proposed as parameters to establish the authenticity of and can possibly help to differentiate the drug from its other species.The presence study demonstrates the presence of some phytochemicals in various extracts and glycosides, saponins , tannins confirmed by HPTLC instrument of Camag system.

Keywords

Euphoria longan, HPTLC, Proximate Analysis, Physico-Chemical Investigations.

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P. Muthumani ¹, R. Meera ¹, Pratesh ¹, N. Chidambaranathan ¹, P. Devi ¹, B. Kameswari ¹

Affiliations
1 K.M. College of Pharmacy, Uthangudi, Madurai-625107, Tamil Nadu, IN

Abstract

A new series of substituted 4-thiazolidionones were synthesized by cyclization of Schiff’s bases with thiooglycollic acid. The substituted schiff’s bases were synthesized starting from substituted benzoic acid with thionyl chloride in 3 steps. The structures of the synthesized compounds have been established on the basis of physical and spectral data and are screened for anticonvulsant, antibacterial and anti hyperglycemic activities; some of them exhibited significant activity.

Keywords

Substituted 4-Thiazolidinonnes, Anticonvulsant, Anti Hyperglycemic, Anti Bacterial.

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R. Meera ¹, P. Devi ², B. Madhumitha ³, B. Kameswari ³

Affiliations
1 Department of Pharmaceutical Chemistry, K. M. College of Pharmacy, Madurai-625107 Tamilnadu, IN
2 Department of Pharmacognosy, K. M. College of Pharmacy, Madurai-625107 Tamilnadu, IN
3 Department of Biochemistry, K. M. College of Pharmacy, Madurai-625107, Tamilnadu, IN

Abstract

Anti microbial activity of Ether, Acetone Dichloromethane extract and Choloroform extracts and semi synthetic derivatives of Rimelia reticulata were tested against Gram (+) and Gram (-) bacteria strains using zone of inhibition by Agar disc diffusion method.. The bacteria used in test were Gram positive (Staphylococus aureus, Bacillus subtilis and Micrococcus luteus and Gram negative (Escherichia coli, Salmonella typhi and Pseudomonas aureginosa). Moderate antibacterial activity for Ether and Dichloromethane extract, and in Chloroform extract having more than 100% activity and Acetone extract having (90%) activity in Gram (+) organism. In Gram (-) all the extracts having moderate activity (80%). In Semi synthetic derivatives of Rimelia reticulata the Gram (+) and Gram (-) organisms are used. Among the four derivatives 2,4 di nitro hydrazine derivative has more than (100%) activity and 4 nitro phenyl hydrazine, phenyl hydrazine having moderate (80%) activity against Gram (+). In Gram (-) Hydrazine hydrate has shown more than (100% ) and Phenyl hydrazine, 4 nitro phenyl hydrazine having (90%) activity. The standard drug used in this activity is Lincomycin. Based on the current findings it can be concluded that the lichen Rimelia reticulata posses potent antibacterial activity.

Keywords

Rimelia reticulata, Antibacterial Activity, Agar Disc Diffusion Method, Crude Extracts, Semi Synthetic Derivatives.

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N. J. Merlin ¹, V. Parthasarathy ¹, R. Manavalan ¹, P. Devi ², R. Meera ²

Affiliations
1 Annamalai University, Annamalai Nagar-608002, Tamil Nadu, IN
2 K.M. College of Pharmacy, Uthangudi, Madurai-625107, Tamilnadu, IN

Abstract

Apoptosis, a form of programmed cell death, is a pivotal defense against the occurrence of cancer and is essential to metazoans in maintaining tissue homeostasis. Apoptosis exhibits a distinctive phenotype and involves elimination of potentially deleterious cells. Many diseases have been associated with aberrantly regulated apoptotic cell death, ultimately leading to inhibition of apoptosis and propagation of diseases such as cancer. This review highlights the significance of apoptosis, molecular mechanisms of apoptosis and various methods of causing cell death.

Keywords

Apoptosis, Programmed Cell Death, Significance, Mechanisms, Caspases, Bcl-2 Family.

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R. Badmanaban ¹, C. N. Patel ¹, P. Devi ², R. Meera ², B. Kameswari ², B. Eswarapriya ³

Affiliations
1 Shri Sarvajanik Pharmacy College, Mehasana, North Gujarat, IN
2 K.M. College of Pharmacy, Uthangudi, Madurai, IN
3 St. Michael College of Engineering, Kalayarkovil, Tamilnadu, IN

Abstract

Formulated oil a Siddha formulation was developed using two plant drugs namely Pongamia pinnata seeds and Boerhaavia diffusa ischolar_mains. Preliminary physio chemical screening was performed in both the plants. The wound healing activity was studied with comparison of Sesame oil and Formulated oil by using standard nitro furazone ointment. The methods used were Excision wound model, Incision wound model and Dead space wound model. In excision and incision wound model the formulated oil treated group showed much greater increase in the tensile strength when compared to the control, which was almost similar to that of nitro furazone. In the dead space wound model both the sesame oil and formulated oil produced a significant increase in the wet granuloma tissue weight as well as in the dry weight .Tensile strength was also found to be increased (P<0.001) in both of the oil treated groups.

Keywords

Pongamia pinnata, Boerhaavia diffusa, Sesame Oil, Formulated Oil, Wound Healing Activity.

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N. J. Merlin ¹, V. Parthasarathy ¹, R. Manavalan ¹, P. Devi ², R. Meera ³

Affiliations
1 Department of Pharmacy, Annamalai University, Annamalai Nagar-608002, Tamilnadu, IN
2 Department of Pharmacognosy, K. M. College of Pharmacy, Uthangudi, Madurai-625107, Tamilnadu, IN
3 Department of Pharmaceutical Chemistry, K. M. College of Pharmacy, Uthangudi, Madurai-625107, Tamilnadu, IN

Abstract

The present study was carried out to investigate the anti inflammatory, anti bacterial and anti fungal activity of of petroleum ether, chloroform, ethyl acetate and ethanolic extract obtained from Gmelina asiatica. All the extracts were prepared from aerial parts of Gmelina asiatica by hot percolation method in soxhlet apparatus. All extracts of Gmelina asiatica were tested for antibacterial efficacy against Bacillus subtilis, Staphylococcus aureus, Micrococcus luteus, Escherichia coli, Salmonella typhi and pseudomonas aeruginosa and antifungal efficacy against Candida albicans and Aspergillus niger. The Antibacterial and Anti fungal effect produced by petroleum ether, chloroform, ethyl acetate and ethanol extract were comparable to that of Amikacin and Griseofulvin. The Chloroform extract was found to be more effective and showed Anti bacterial and antifungal activity against the entire organism tested. All the extracts at dose concentration (500 mg/kg) were screened for antimicrobial activity. The ethanolic extract of Gmelina asiatica at (250 and 500 mg/kg) concentrations exhibited anti inflammatory activity in carrageenan induced rat paw oedema, histamine induced odema, dextran induced odema and cotton pellet induced granuloma method, and the results are compared to that of standard drug Indomethacin. The results were found to be significiant (P<0.001) when compared to control.

Keywords

Gmelina asiatica, Anti-Inflammatory Activity, Indomethacin, Antimicrobial Activity, Amikacin, Anti Fungal Activity, Griseofulvin.

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